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Research Fellow (Natural Sciences and Science Education Academic Group) [RS 2/16 YYK]

  • The National Institute of Education invites suitable applications for the position of Research Fellow (contract position) at the Natural Sciences and Science Education Academic Group (NSSE).

    Project Title

    G-Quadruplex-Targeting Anticancer Metal Complexes: Biological Effects and Molecular Mechanisms

     Project Introduction

    The aim of this project is to design G-quadruplex-binding anticancer metal complexes, characterize their interaction with DNA, and study their modes of action on cancer cells. The success of the metal-based anti-cancer drug, Cisplatin, has provided considerable impetus for the search for new metallodrugs with a broader spectrum of action and lower side-effects. G-quadruplexes are four-stranded DNA structures that can be formed from guanine-rich sequences in telomeres and the promoter regions of some oncogenes. The activity of telomerase, an enzyme that is crucial for the immortalization of cancerous cells, can be inhibited if the single-stranded telomeric DNA is folded into a quadruplex structure. Formation of quadruplex structures in the promoter regions of oncogenes like c-myc and c-kit has been proposed to regulate the transcription of these genes. Metal complexes that bind to, and stabilize, quadruplex DNA are therefore of interest as potential anticancer agents. Such compounds are promising candidates for potent and target-specific anticancer drugs with low toxicity.

    We are currently seeking a full-time Research Fellow to lead in the design and synthesis of novel G-quadruplex-targeting metal complexes and the investigation of their molecular modes of action. 

    • PhD degree in Biological Chemistry
    • Deep understanding and hands-on experience in the following:
      - organometallic synthesis
      - nuclear magnetic resonance, infrared, UV-vis and mass spectroscopic analyses
      - microscopy 
      - cell culturing and cytotoxicity assays
    • Must have strong problem solving and analytical skills
    • Able to work as a team and communicate well
    • The ideal candidate must be highly self-motivated and must enjoy hands-on work
    • Lead in design and synthesis of novel G-quadruplex-targeting metal complexes and the investigation of their molecular modes of action
    • Plan and execute experiments; analyse, evaluate and interpret results independently
    • Assist in supervising research students
    • Communicate with research collaborators
    • Prepare grant proposals, academic papers and technical reports
  • Applicants should complete and submit the following item/s:

    • Application form for Research Positions
    • Cover letter explaining how you meet the requirements of this position
    • Supporting documents as stated on the job application form
    • Other documents to support your qualifications

    Please send your application to:
    Associate Professor Yan Yaw Kai (PhD)
    Head, Natural Sciences & Science Education
    National Institute of Education
    1 Nanyang Walk
    Singapore 637616
    Email: yawkai.yan@nie.edu.sg

    **We regret that only shortlisted applicants will be notified**

  • 28 February 2018
  • NIE staff can take chartered buses at their own expense from or near their homes to the NIE campus. This is subject to availability of seats.