The National Institute of Education invites suitable applications for the position of Research Fellow (contract position) at the Natural Sciences and Science Education Academic Group (NSSE).
G-Quadruplex-Targeting Anticancer Metal Complexes: Biological Effects and Molecular Mechanisms
The aim of this project is to design G-quadruplex-binding anticancer metal complexes, characterize their interaction with DNA, and study their modes of action on cancer cells. The success of the metal-based anti-cancer drug, Cisplatin, has provided considerable impetus for the search for new metallodrugs with a broader spectrum of action and lower side-effects. G-quadruplexes are four-stranded DNA structures that can be formed from guanine-rich sequences in telomeres and the promoter regions of some oncogenes. The activity of telomerase, an enzyme that is crucial for the immortalization of cancerous cells, can be inhibited if the single-stranded telomeric DNA is folded into a quadruplex structure. Formation of quadruplex structures in the promoter regions of oncogenes like c-myc and c-kit has been proposed to regulate the transcription of these genes. Metal complexes that bind to, and stabilize, quadruplex DNA are therefore of interest as potential anticancer agents. Such compounds are promising candidates for potent and target-specific anticancer drugs with low toxicity.
We are currently seeking a full-time Research Fellow to lead in the design and synthesis of novel G-quadruplex-targeting metal complexes and the investigation of their molecular modes of action.