Moderate exercise and postprandial triglycerides in overweight Asians: issues of dose response

Project Number
RI 5/15 SB

Project Duration
June 2016 - May 2019

Status
In-Progress

Abstract
Postprandial triglyceride (TG) refers to the major form of fat in the blood found after eating and high concentrations of postprandial TG are associated with cardiovascular disease. Evidence suggests that South Asians suffer from exaggerated postprandial TG concentrations compared with individuals of European origin but there are no comparisons of postprandial TG among Asians of differing ethnicity. Exercise can reduce postprandial TG in European and South Asian men. However, little is known about the optimal dose of exercise needed for TG reductions in Asians. Current public health guidelines in Singapore and by the World Health Organisation suggest adults should complete ~30 minutes of moderate intensity physical activity each day. However, these guidelines originate from data and evidence mostly collected in Western populations and the applicability to individuals of Asian origin is questionable. Studies are needed to clarify the exercise dose-response for Asians with respect to cardiovascular disease risk factors in order to improve and develop ‘ethnic centric’ public health guidelines in Asian countries. Thus, the specific aims of the present proposal are: Specific Aim 1: To compare postprandial TG concentrations in overweight Chinese, Indian and Malay men. Specific Aim 2: To investigate and compare the dose-response relationship between exercise energy expenditure and postprandial TG in overweight Chinese, Indian and Malay men. The proposed research project will be the first to examine differences in postprandial TG in Asians of different ethnic origins. Moreover, it will provide important evidence related to the exercise prescription needed to ameliorate this risk factor. Data from this study will assist in the prevention of cardiovascular disease in Singapore and contribute to public health recommendations. The Principal Investigator (PI) and Collaborator have an established history of studying postprandial TG metabolism at NIE and previous institutions with the proposed experiment continuing this theme.

Funding Source
NIE

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